7110860
Tocris Bioscience™ Hydroxychloroquine sulfate
Autophagy inhibitor; also TLR9 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 747-36-4
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Chemical Name or Material
2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Target
Autophagy-related Compounds
Formula Weight
433.95
CAS
747-36-4
Molecular Formula
C18H28ClN3O5S
Purity
>99%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ Hydroxychloroquine sulfate | -- | ₹ 12,931.70 | ||
Tocris Bioscience™ Hydroxychloroquine sulfate | -- | ₹ 53,622.50 | ||
2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol, MilliporeSigma™ Supelco™ | -- | ₹ 25,632.00 | ||
Selleck Chemical LLC Hydroxychloroquine Sulfate 10mg 747-36-4 HCQ | -- | ₹ 15,699.60 | ||
Hydroxychloroquine sulfate | -- | ₹ 6,007.88 | ||
Hydroxychloroquine sulfate | -- | ₹ 40,756.13 | ||
2-[4-[(7-Chloro-4-quinolinyl)amino]pentyl] amino ethanol | -- | ₹ 25,103.18 | ||
Hydroxychloroquine sulfate | -- | ₹ 21,401.03 | ||
747-36-4 | 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; sulfuric acid | -- | ₹ 890.00 - ₹ 65,860.00 |
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Description
- Autophagy inhibitor
- Inhibits growth and induces apoptosis of renal cancer cells in vitro
- Also inhibits TLR9
- Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro
- Hydroxychloroquine sulfate is an autophagy inhibitor
- Also inhibits TLR9
- Inhibits growth and induces apoptosis of renal cancer cells in vitro
- Additionally inhibits PRC2 by inhibiting the allosteric binding of PRC2 to EED (embryonic ectoderm development) within the H3K27me3-binding pocket, and reduces H3K27me3 levels in multiple myeloma cells in vitro
- Inhibits SARS-CoV-2 viral infection, in vitro (EC50 values in μM range and dependent on viral RNA copy number)
- Hydroxychloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro
- Also antimalarial and immunomodulator
- Tocris products are for biomedical research use only
- They are not intended for human or veterinary use.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C