Description

• General description: Isorhamnetin is an O-methylated flavonol [1] found in fruits, plants, and medicinal herbs. It is a metabolite of quercetin.[2]
• Application: Isorhamnetin (IRN) has been used:as a neuroprotective agent to test its effect on scopolamine-induced cortico-hippocampal learning and memory deficiency in mice[3]as a reference standard in quadrupole time-of-flight mass spectrometry (QTOF MS) to analyze and quantify the phenolic compounds present in honey extract[4]as a reference standard to determine the phenolic profile of Artemisia species using Reversed-phase high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry (RP-HPLC-DAD-ESI-TQ-MS/MS)[5]
• Biochem/physiol Actions: Isorhamnetin exerts antioxidant, anti-inflammatory, anti-cancer, anti-bacterial, and anti-viral effects.[6] It has shown to be a potential neuroprotective agent by inhibiting neurodegeneration in the hippocampus under Diabetes mellitus (DM) conditions.[1] Isorhamnetin at low levels may serve as an anti-diabetic agent by promoting glucose uptake in skeletal muscle cells and maintaining glucose homeostasis in hyperglycemic conditions.[2] It regulates cell signaling pathways such as Nuclear factor kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK) etc.[6] Isorhamnetin elicits protective and therapeutic effects on atherosclerosis and cardiovascular diseases.[6]
• Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.