PHL89745
Oridonin
phyproof® Reference Substance
Manufacturer: Sigma Aldrich
CAS Number: 28957-04-2
Synonym(S): 7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one, Isodonol
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 MG | PHL89745-10-MG | In Stock | ₹ 42,791.23 |
PHL89745 - 10 MG
In Stock
Quantity
1
Base Price: ₹ 42,791.23
GST (18%): ₹ 7,702.421
Total Price: ₹ 50,493.651
grade
primary reference standard
product line
phyproof® Reference Substance
Assay
≥98.0% (HPLC)
manufacturer/tradename
PhytoLab
application(s)
food and beverages
format
neat
InChI
1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3/t10-,11-,12-,13+,15+,16-,18+,19-,20+/m0/s1
InChI key
SDHTXBWLVGWJFT-XKCURVIJSA-N
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Sigma Aldrich Fine Chemicals Biosciences Oridonin >=98% (HPLC), solid | 28957-04-2 | 5MG | -- | ₹ 16,027.12 | ||
Sigma Aldrich Fine Chemicals Biosciences Oridonin >=98% (HPLC), solid | 28957-04-2 | 25MG | -- | ₹ 61,730.40 | ||
Indofine Chemical ORIDONIN, Herbal Standards, 28957-04-2, >98% by HPLC, 20 mg | -- | ₹ 16,990.10 | ||
Selleck Chemical LLC Oridonin 10mg 28957-04-2 Isodonol, Rubescenin, NSC-250682 | -- | ₹ 7,476.00 | ||
Oridonin | -- | ₹ 3,115.00 - ₹ 50,908.00 |
Description
- General description: This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
- Biochem/physiol Actions: Oridonin has potent anti-tumor activity. Oridonin targets AE (AML1-ETO) oncoprotein. Exposure to oridonin induces apoptosis in AE-bearing leukemic cells through the activation of intrinsic apoptotic pathway and triggering a caspase-3-mediated degradation of AE at D188. The compound also prolonged the lifespan of C57 mice bearing truncated AE-expressing leukemic cells without side effects like suppression of bone marrow or reduction of body weight of animals, and exerted synergic effects while combined with cytosine arabinoside. Additionally, oridonin inhibited tumor growth in nude mice inoculated with t(8;21)-harboring Kasumi-1 cells.
- Legal Information: phyproof is a registered trademark of PhytoLab GmbH & Co. KG
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable