PHR1540
Letrozole
Pharmaceutical Secondary Standard; Certified Reference Material
Manufacturer: Supelco
CAS Number: 112809-51-5
Synonym(S): Letrozole, 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 G | PHR1540-1-G | In Stock | ₹ 11,907.50 |
PHR1540 - 1 G
In Stock
Quantity
1
Base Price: ₹ 11,907.50
GST (18%): ₹ 2,143.35
Total Price: ₹ 14,050.85
grade
certified reference materialpharmaceutical secondary standard
Quality Level
300
Agency
traceable to Ph. Eur. Y0000685traceable to USP 1356971
API family
letrozole
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitablegas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Letrozole Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™ | -- | ₹ 14,124.30 | ||
Sigma Aldrich Fine Chemicals Biosciences Letrozole United States Pharmacopeia (USP) Reference Standard | 112809-51-5 | MFCD00866241 | 200MG | -- | ₹ 47,632.80 | ||
Letrozole | -- | ₹ 24,962.45 | ||
Letrozole | -- | ₹ 14,267.35 | ||
112809-51-5 | 4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile | -- | ₹ 3,560.00 - ₹ 95,586.00 |
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Description
- General description: Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Letrozole is used for the treatment of breast cancer in hormone-dependent postmenopausal patients. The drug works by blocking the synthesis of estrogen, a causative agent for cancer.[1]
- Application: Letrozole may be used as a pharmaceutical reference standard for the determination of the analyte in biological/environmental samples[1][2] and pharmaceutical formulations[3] by various chromatography techniques.
- Biochem/physiol Actions: Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
- Analysis Note: These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
- Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
- Footnote: To see an example of a Certificate of Analysis for this material enter LRAA4186 in the slot below. This is an example certificate only and may not be the lot that you receive.
- Recommended products: Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - STOT RE 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable