01-671-857
Factor XII Light chain Monoclonal Antibody (C6B7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-671-857-Each-of-1 | In Stock | ₹ 50,062.50 |
01-671-857 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,062.50
GST (18%): ₹ 9,011.25
Total Price: ₹ 59,073.75
Antigen
Factor XII Light chain
Classification
Monoclonal
Concentration
3.0 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
P00748
Gene Symbols
F12
Immunogen
Purified human Factor XII.
Quantity
250 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA
Clone
C6B7
Conjugate
Unconjugated
Gene
F12
Gene Alias
Beta-factor XIIa part 1; beta-factor XIIa part 2; Coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; Factor 12; Factor12; FXII; HAE3; HAEX; HAF; Hageman factor
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
2161
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-10829 detects Factor XII, light chain, from human samples
- MA1-10829 has been successfully used in ELISA applications
- The MA1-10829 immunogen is purified human Factor XII
- This gene encodes coagulation factor XII which circulates in blood as a zymogen
- This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain
- The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain
- On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain
- Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa
- The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
- It activates coagulation factors VII and XI
- Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.