Quinidine Monoclonal Antibody (QD14-504.5), Invitrogen™

Description

• MA1-10750 detects Quinidine
• MA1-10750 has been successfully used in ELISA applications
• The MA1-10750 immunogen is Quinidine, conjugated to KLH
• Quinidine is an alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects
• Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential
• In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses
• Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme
• This results in accumulation of toxic heme and death of the parasite
• [National Center for Biotechnology Information
• PubChem Compound Database; CID=441074].