01-674-652
MELK Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-652-Each-of-1 | In Stock | ₹ 46,502.50 |
01-674-652 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
MELK
Classification
Polyclonal
Conjugate
Unconjugated
Gene
MELK
Gene Alias
AI327312; hMELK; HPK38; Kiaa0175; Maternal embryonic leucine zipper kinase; Melk; mKIAA0175; MPK38; OTTHUMP00000046113; pEg3 kinase; Pk38; Protein kinase Eg3; protein kinase PK38; RP11-8N6.1; Tyrosine-protein kinase MELK
Host Species
Goat
Purification Method
Ammonium sulfate precipitation
Regulatory Status
RUO
Gene ID (Entrez)
9833
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.5 mg/mL
Formulation
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q14680
Gene Symbols
MELK
Immunogen
Synthetic peptide corresponding to the C terminus amino acids KRLVEDILSSCKV.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with bovine, canine and mouse based on sequence homology
- This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000
- MELK is a serine/threonione kinase which is related to the AMPK family that has been linked to the cell cycle
- MELK has also been shown to be overexpressed in cancer and has been identified has a potential target for cancer therapeutics
- MELK has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622
- Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1
- Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis
- Plays a key role in cell proliferation and carcinogenesis
- Required for proliferation of embryonic and postnatal multipotent neural progenitors
- Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14
- Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus
- May also play a role in primitive hematopoiesis.