01-675-744
Anthrax Lethal Factor Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-744-Each-of-1 | In Stock | ₹ 49,261.50 |
01-675-744 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,261.50
GST (18%): ₹ 8,867.07
Total Price: ₹ 58,128.57
Antigen
Anthrax Lethal Factor
Classification
Polyclonal
Conjugate
Unconjugated
Gene Alias
Anthrax LF
Immunogen
Synthetic peptide corresponding ot residues 47-65 of Anthrax lethal factor.
Regulatory Status
RUO
Target Species
Bacteria
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.2% gelatin and 0.05% sodium azide
Host Species
Rabbit
Quantity
200 μL
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Suggested positive control: recombinant protein
- Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores
- B
- anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF)
- PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant
- Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease
- The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm
- LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.