CD43 Monoclonal Antibody (MEM-59), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-882-Each-of-1 | In Stock | ₹ 44,277.50 |
01-675-882 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,277.50
GST (18%): ₹ 7,969.95
Total Price: ₹ 52,247.45
Antigen
CD43
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
P16150
Gene Symbols
SPN
Immunogen
Human T lymphocytes.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
MEM-59
Conjugate
Unconjugated
Gene
SPN
Gene Alias
3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
6693
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 μm filter sterilized
- Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test
- Functional Application: Induction
- CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells
- CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation
- By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic
- CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors
- Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability
- CD43 appears to be an important modulator of leukocyte functions
- Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.