CD47 Monoclonal Antibody (MEM-122), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-889-Each-of-1 | In Stock | ₹ 38,448.00 |
01-675-889 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,448.00
GST (18%): ₹ 6,920.64
Total Price: ₹ 45,368.64
Antigen
CD47
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 15mM sodium azide; pH 8
Gene Accession No.
Q08722, Q9GKE8
Gene Symbols
CD47
Immunogen
COS-7 (African green monkey) cells.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Non-human Primate, Porcine
Product Type
Antibody
Isotype
IgM
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Western Blot
Clone
MEM-122
Conjugate
Unconjugated
Gene
CD47
Gene Alias
9130415E20Rik; AA407862; AI848868; antigen identified by monoclonal antibody 1D8; antigenic surface determinant protein OA3; AW108519; B430305P08Rik; Cd47; CD47 antigen; CD47 antigen (Rh-related antigen, integrin-associated signal transducer); CD47 antigen/integrin-associated protein; CD47 glycoprotein; CD47 molecule; CD47/IAP; IAP; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; Itgp; Leukocyte surface antigen CD47; MER6; OA3; Protein MER6; Rh-related antigen; sCD47; soluble CD 47; soluble CD47
Host Species
Mouse
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
397042, 961
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- This antibody is purified from ascites by CHT-chromatagraphy and precipitation methods
- CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions
- Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins
- Functionally, CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix
- CD47 is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction
- CD47 has broad tissue distribution, is reduced in expression on Rh erythrocytes
- CD47 acts as a ligand for CD172a (signal regulatory protein alpha, SIRP alpha), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells
- Moreover, CD47-CD172a system affects cell migration, B cell adhesion, T cell activation, and is involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.