CD34 Monoclonal Antibody (4H11[APG]), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-675-993-Each-of-1 | In Stock | ₹ 39,872.00 |
01-675-993 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,872.00
GST (18%): ₹ 7,176.96
Total Price: ₹ 47,048.96
Antigen
CD34
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P28906
Gene Symbols
Cd34
Immunogen
Permanent human cell line from a patient with myeloid leukaemia.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
4H11[APG]
Conjugate
Unconjugated
Gene
Cd34
Gene Alias
(E3-independent) E2 ubiquitin-conjugating enzyme R1; AU040960; CD34; CD34 antigen; CD34 molecule; CDC34; cell division cycle 34; cell division cycle 34 homolog; cluster designation 34; cluster of differentiation antigen 34; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell marker CD34; Mucosialin; RP11-328D5.2; sialomucin protein; type 1 transmembrane protein; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
947
Content And Storage
4° C, do not freeze
Form
Liquid
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Description
- For Western blot, a positive control of KG-1a human leukemia cell lysate is suggested
- For paraffin sections, a positive control of placenta endothelium is suggested
- Western Blot: non-reducing conditions
- CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations
- CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible
- CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors
- CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions
- CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells
- Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components
- CD34 is thought to have a role in presenting carbohydrate ligands to selectins
- The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction
- Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.