CD22 Monoclonal Antibody (MEM-01), Biotin, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-241-Each-of-1 | In Stock | ₹ 43,654.50 |
01-676-241 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,654.50
GST (18%): ₹ 7,857.81
Total Price: ₹ 51,512.31
Antigen
CD22
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P20273
Gene Symbols
CD22
Immunogen
Burkitt's lymphoma cell line Raji.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Non-human Primate
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunoprecipitation, Western Blot
Clone
MEM-01
Conjugate
Biotin
Gene
CD22
Gene Alias
A530093D23; B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; B-lymphocyte cell adhesion molecule (BL-CAM); Cd22; CD22 antigen; CD22 molecule; FLJ22814; Lectin 2; Leu-14; Lyb8; Lyb-8; MGC130020; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; Sialic acid-binding Ig-like lectin 2 (Siglec-2); Siglec2; Siglec-2; T-cell surface antigen Leu-14
Host Species
Mouse
Purification Method
Size-exclusion chromatography
Regulatory Status
RUO
Gene ID (Entrez)
933
Content And Storage
4° C, do not freeze
Form
Liquid
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Description
- CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa
- CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes
- CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen
- Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias
- CD22 is also strongly expressed in hairy cell leukemia
- CD22 preferentially binds to alpha2,6-linked sialic acid
- The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface
- Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling
- CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules
- CD22 is also strongly expressed in hairy cell leukemia
- CD22 is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.