Macrophages/Monocytes Monoclonal Antibody (ER-HR3), Invitrogen™

Description

• MA1-40078 detects Monocytes/Macrophages from mouse samples
• MA1-40078 is specially reactive to the monocytes and macrophages located in hemopoietic organs
• Whereas all other leukocytes are ER-HR3 negative, up to 70% of circulating monocytes stain positive with this monoclonal antibody
• Furthermore, about 30% of bone marrow cells express the antigen
• Other positive macrophages can be found in the splenic red pulp, in the mesenteric lymphoid paracortex, interfollicular areas of Peyer’s patches and bone marrow
• Few positive cells are observed in the thymic cortex and the connective tissues of the gastro-intestinal tract, the dermis and the renal medulla
• Epidermal Langerhans cells also express the antigen
• MA1-40078 has been successfully used in immunohistochemistry (paraffin and frozen) and flow cytometry applications
• The MA1-40078 immunogen is mouse monocytes and macrophages
• Macrophages are a large phagocytic cell found in stationary form in the tissues or as a mobile white blood cell, especially at sites of infection
• Monocytes are a large phagocytic white blood cell with a simple oval nucleus and clear, grayish cytoplasm
• Monocytes and macrophages are found in interdigitating cells and activated microglia cells.