01-676-749
LIME Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-676-749-Each-of-1 | In Stock | ₹ 40,406.00 |
01-676-749 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,406.00
GST (18%): ₹ 7,273.08
Total Price: ₹ 47,679.08
Antigen
LIME
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Lime1
Gene Alias
2810038K19Rik; dJ583P15.4; FLJ20406; Lck interacting transmembrane adaptor 1; lck-interacting membrane protein; Lck-interacting molecule; lck-interacting transmembrane adapter 1; Lime; lime 1; LIME1; LP8067; RP4-583P15.5
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
54923
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
Q9H400
Gene Symbols
Lime1
Immunogen
Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody reacts with the cytoplasmic domain of LIME, and will not cross-react with mouse
- LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells
- After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk
- Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling
- However, under some circumstances, LIME may mediate inhibitory signals.