HP1 alpha Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-950-251-Each-of-1 | In Stock | ₹ 46,502.50 |
01-950-251 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HP1 alpha
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cbx5
Gene Alias
2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
Host Species
Rabbit
Purification Method
IgG fraction
Regulatory Status
RUO
Gene ID (Entrez)
23468
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Concentration
13 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
P45973
Gene Symbols
Cbx5
Immunogen
Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is expected to cross-react with mouse, Arabidopsis suecica, Rye, and Triticum aestivum based on sequence homology
- Suggested positive control: antigen standard for CBX5 (transient overexpression lysate), Hela whole cell extract
- Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing
- It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure
- High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain
- Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3
- In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.