KIR2DL3 Monoclonal Antibody (GL183), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01672411-Each-of-1 | In Stock | ₹ 99,947.00 |
01672411 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 99,947.00
GST (18%): ₹ 17,990.46
Total Price: ₹ 1,17,937.46
Antigen
KIR2DL3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA and 0.09% sodium azide
Gene Accession No.
P43628
Gene Symbols
KIR2DL3
Immunogen
NK cell clone E57.
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunoprecipitation
Clone
GL183
Conjugate
Unconjugated
Gene
KIR2DL3
Gene Alias
CD158 antigen-like family member B2; CD158b; CD158B2; CU464054.1; GL183; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3; killer cell immunoglobulin-like receptor 2DL3; killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 3; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; killer Ig-like inhibitory receptor; killer inhibitory receptor cl 2-3; KIR-023GB; KIR2DL3; KIR2DS3; KIR2DS5; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; MHC class I NK cell receptor; natural killer associated transcript 2; natural killer cell inhibitory receptor KIR2DL3; natural killer cell receptor; natural killer-associated transcript 2; NKAT; NKAT2; NKAT-2; NKAT2A; NKAT2B; NK-receptor; p58; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I specific NK receptor; p58.2 MHC class-I-specific NK receptor
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
3804
Content And Storage
4° C
Form
Liquid
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Description
- Natural killer (NK) cells in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells
- NK cells are important effectors of innate immunity where they release cytokines, which in turn up-regulate other immunological functions
- Monoclonal antibodies have been used to identify different surface antigens present on NK cells
- These surface antigens have not only been used to identify NK cells, but also their functionally distinct subsets
- The Cluster of Differentiation (CD) nomenclature was established to standardize the naming of NK cells
- NKAT (NK-associated transcripts) gene products, known as killer immuno-globulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells
- This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM)
- KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I/VxYxxL/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif)
- The human inhibitory human killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3), also referred to as CD158b, is an inhibitory receptor that is specific for the human MHC class I molecule HLA-Cw3 and related alleles.