Home Products Antibodies Primary Antibodies 05 637 AF488
05-637-AF488

MilliporeSigma™ Mouse anti-Bmi-1, Clone: F6, Alexa Fluor 488,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 05-637-AF488-Each-of-1 In Stock ₹ 61,151.90

05-637-AF488 - Each of 1

₹ 61,151.90

In Stock

Quantity

1

Base Price: ₹ 61,151.90

GST (18%): ₹ 11,007.342

Total Price: ₹ 72,159.242

Antigen

Bmi-1

Classification

Monoclonal

Conjugate

Alexa Fluor 488

Gene Accession No.

P25916

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human, Monkey

Form

Purified

Applications

Immunocytochemistry

Clone

F6

Formulation

Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.

Gene Symbols

BMI1; PCGF4; RNF51

Immunogen

Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.

Quantity

100 μL

Research Discipline

Epigenetics and Nuclear Function

Gene ID (Entrez)

NP_031578.2

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

Isotype

IgG1

Description

  • Specifically detects Bmi-1 clone: F6 in Human, Monkey samples, and it is validated for Immunocytochemistry Polycomb complex protein BMI-1 (UniProt P25916; also known as B lymphoma Mo-MLV insertion region 1, Polycomb group RING finger protein 4) is encoded by the Bmi1 (also known as AW546694, Bmi-1, Pcgf4) gene (Gene ID 12151) in murine species
  • Bmi1 is a member of the polycomb group (PcG) family of evolutionarily conserved gene silencers involved in cell fate decisions and body pattern during development
  • Bmi1 is an important regulator of self-renewal of hematopoietic and neural stem cells, as well as cancer stem cells (CSCs)
  • Bmi1 is a main constituent of the polycomb repressive complex 1 (PRC1) and pariticipates in PRC-mediated gene silencing by promoting monoubiquitination of H2A
  • Bmi1 overexpression is reported in many different human cancers and high level of Bmi1 is considered as a poor prognostic marker
  • Bmi1 targets genes involved in transforming growth factor-β/bone morphogenetic protein (TGF-beta/BMP), endoplasmic reticulum (ER) stress, and WNT pathways
  • Bmi itself is transcriptionally regulated by c-Myc and E2F1 transcription factors.