06-284-AF647
MilliporeSigma™ anti-Nitrotyrosine, Alexa Fluor 647, Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 06-284-AF647-Each-of-1 | In Stock | ₹ 55,893.78 |
06-284-AF647 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,893.78
GST (18%): ₹ 10,060.88
Total Price: ₹ 65,954.66
Antigen
Nitrotyrosine
Classification
Polyclonal
Formulation
Purified rabbit antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.
Immunogen
Nitratred KLH.
Quantity
100 μL
Research Discipline
Signaling
Test Specificity
Recognizes proteins which are nitrated.
Content And Storage
2°C to 8°C for one year
Applications
Immunohistochemistry
Conjugate
Alexa Fluor 647
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects Nitrotyrosine Clone: in Human samples, and it is validated for Immunohistochemistry Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species
- Proteins are often targets of reactive species and detection of oxidatively modified proteins is often used as an index of oxidative stress
- Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide
- The reaction of proteins with peroxynitrite results in the oxidation of tryptophan and cysteine, as well as the nitration of tyrosine, formation of dityrosine, 2,4 dinitrophenylhydrazine-reactive carbonyls, and protein fragmentation
- The formation of 3-nitrotyrosine represents a specific peroxynitrite-mediated protein modification that is different from modifications mediated by reactive oxygen species
- Studies show that elevated nitrotyrosine levels are associated with inflammatory conditions, such as atherosclerotic plaques and rheumatoid arthritis.