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06-519-AF488

MilliporeSigma™ Rabbit anti-phospho-CREB (Ser133), Alexa Fluor 488, Polyclonal,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 06-519-AF488-Each-of-1 In Stock ₹ 42,968.31

06-519-AF488 - Each of 1

₹ 42,968.31

In Stock

Quantity

1

Base Price: ₹ 42,968.31

GST (18%): ₹ 7,734.296

Total Price: ₹ 50,702.606

Antigen

phospho-CREB (Ser133)

Classification

Polyclonal

Formulation

Purified rabbit polyclonal antibody conjugate in PBS with 15mg/mL BSA and 0.1% sodium azide.

Gene Symbols

CREB1

Immunogen

KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A.

Quantity

100 μL

Research Discipline

Epigenetics and Nuclear Function

Gene ID (Entrez)

NP_604391

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

Applications

Immunofluorescence

Conjugate

Alexa Fluor 488

Gene Accession No.

P16220

Host Species

Rabbit

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Isotype

IgG1

Description

  • Specifically detects phospho-CREB (Ser133) in Human, Mouse, Rat samples, and it is validated for Immunofluorescence Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human
  • CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes
  • CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca 2+ /calmodulin-dependent protein kinases
  • Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2
  • CREB is critical for memory formation across a wide range of species.