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06-599-AF647

MilliporeSigma™ Rabbit anti-acetyl-Histone H3, Alexa Fluor 647, Polyclonal

Manufacturer: MilliporeSigma™

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Pack Size SKU Availability Price
Each of 1 06-599-AF647-Each-of-1 In Stock ₹ 60,441.68

06-599-AF647 - Each of 1

₹ 60,441.68

In Stock

Quantity

1

Base Price: ₹ 60,441.68

GST (18%): ₹ 10,879.502

Total Price: ₹ 71,321.182

Antigen

acetyl-Histone H3

Classification

Polyclonal

Formulation

Purified rabbit antibody conjugate in buffer containing PBS, 15mg/mL BSA and 0.1% Sodium Azide.

Gene Symbols

HIST3H3; H3FT

Immunogen

Synthetic peptide corresponding to human histone H3 N-terminal sequence with acetylated Lys9 and Lys14

Quantity

100 μL

Research Discipline

Epigenetics and Nuclear Function

Gene ID (Entrez)

NP_003484.1

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

Applications

Immunocytochemistry

Conjugate

Alexa Fluor 647

Gene Accession No.

Q16695

Host Species

Rabbit

Purification Method

Protein A Purfied

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human, Mouse

Form

Purified

Description

  • Specifically detects acetyl-Histone H3 in Human, Mouse samples, and it is validated for Immunocytochemistry Histone H3 is one of the five main histone proteins that are involved in the structure of chromatin in eukaryotic cells
  • The chromatin fiber is composed on repetitive units, known as nucleosomes, which are comprised of an octamer of core histones (two each of H2A, H2B, H3, and H4), around which DNA are wrapped
  • Histone H3 features a main globular domain and a long N-terminal tail
  • The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes
  • These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine
  • Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that are specifically coordinated in space and time
  • These phosphorylations are initiated at different phases of the cell division
  • Histone H3 variants (H3.1, H3.2 and H3.3) have been implicated in the epigenetic memory of cellular state
  • Genome-wide patterns of H3 are dependent on amino acid sequence and change with cellular differentiation at developmentally regulated loci.