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07-227-6IMI

MilliporeSigma™ Rabbit anti-mSin1, Polyclonal,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 07-227-6IMI-Each-of-1 In Stock ₹ 40,292.08

07-227-6IMI - Each of 1

₹ 40,292.08

In Stock

Quantity

1

Base Price: ₹ 40,292.08

GST (18%): ₹ 7,252.574

Total Price: ₹ 47,544.654

Antigen

mSin1

Classification

Polyclonal

Gene Accession No.

Q9BPZ7

Host Species

Rabbit

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Formulation

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols

MAPKAP1; MIP1; SIN1

Immunogen

KLH-conjugated linear peptide corresponding to the MAP3K2/NBN interaction domain of human mSin1.

Quantity

100 μL

Research Discipline

Signaling

Gene ID (Entrez)

NP_001006618

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

Description

  • Specifically detects mSin1 in Human, Mouse, Rat samples, and it is validated for Immunoprecipitation, Western Blotting Target of rapamycin complex 2 subunit MAPKAP1 (UniProt Q9BPZ7; also known as MEKK2-interacting protein 1, Mitogen-activated protein kinase 2-associated protein 1, mSIN1, Ras inhibitor MGC2745, SAPK-interacting protein 1, Stress-activated protein kinase-interacting 1, Stress-activated map kinase-interacting protein 1,, TORC2 subunit MAPKAP1) is encoded by the MAPKAP1 (also known as JC310, MIP1 SIN1, SIN1b, SIN1g) gene (Gene ID 79109) in human
  • mSIN1 is an essential component of the Torc2 complex
  • mTORC2 is comprised of mTOR, a large Ser/Thr protein kinase, along with mSIN1, GbL (mLST8), Protor1, Protor2, and Rictor
  • The mTORC2 complex is activated primarily downstream of PI3 Kinase and is known to affect cell proliferation and survival primarily by phosphorylating Akt on Ser473
  • Additionally, the mTORC2 complex is known to affect cytoskeletal organization and cell migration by exerting its effects through Rac, Rho, and PKC
  • mSIN1 is also known to directly interact with Ras, SPAKs, and JNK.