Neurogranin, Rabbit anti-Rat, Human, Polyclonal, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 07425I100UG-Each-of-1 | In Stock | ₹ 53,218.44 |
07425I100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,218.44
GST (18%): ₹ 9,579.319
Total Price: ₹ 62,797.759
Antigen
Neurogranin
Classification
Polyclonal
Dilution
Immunohistochemistry (Paraffin) Analysis: A 1:1,000 dilution from a representative lot detected Neurogranin in human and rat brain tissue sections.
Gene Alias
Ng;RC3
Host Species
Rabbit
Molecular Weight of Antigen
∽15 kDa observed; 7.62 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001119653
Target Species
Rat, Human
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
NRGN
Immunogen
KLH-conjugated linear peptide corresponding to 12 amino acids from the C-terminal region of human Neurogranin.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody sepecifically detects Neurogranin. It targets an epitope with in 12 amino acids from the C-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Related Products
Description
- Anti-Neurogranin Antibody, Cat
- No
- 07-425-I, is a highly specific rabbit polyclonal antibody that targets Neurogranin and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Neurogranin (UniProt: Q92686; also known as Ng, RC3) is encoded by the NRGN gene (Gene ID: 4900) in human
- Neurogranin is abundantly expressed in cerebral cortex, hippocampus, amygdala, and striatum
- In neurons, it is found concentrated at dendritic spines
- It acts as a third messenger and serves as a substrate for protein kinase C-mediated molecular cascades during synaptic development and remodeling
- It contains an IQ domain (aa 26-347) and a collagen-like domain (aa 48-78)
- The IQ domain mediates its interaction with calmodulin and phosphatidic acid (PA)
- Neurogranin is intrinsically unstructured, however, upon binding with calmodulin, the IQ domain adopts a helical conformation
- Neurogranin is phosphorylated at serine 36 by protein kinase C and following phosphorylation neurogranin is unable to bind either calmodulin or PA, which can lead to decline in memory-associated functions
- Higher levels of neurogranin have also been reported in brains of elderly and is considered a factor in memory decline, independent of Alzheimer s disease
- (Ref.: Javier Dı´ez-Guerra, F
- (2010)
- Life
- 62(8): 597-606; Casaletto, KB et al
- (2017)
- Neurology 89(17); 1782-1788).