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13-394-0

PCNA Monoclonal Antibody (PC10), Biotin, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 13-394-0-Each-of-1 In Stock ₹ 42,720.00

13-394-0 - Each of 1

₹ 42,720.00

In Stock

Quantity

1

Base Price: ₹ 42,720.00

GST (18%): ₹ 7,689.60

Total Price: ₹ 50,409.60

Antigen

PCNA

Classification

Monoclonal

Concentration

0.2 mg/mL

Formulation

PBS with 1% BSA, 50% glycerol and 0.1% sodium azide; pH 7.4

Gene Accession No.

P04961, P12004, P15873, P17918

Gene Symbols

Pcna, POL30

Immunogen

Rat recombinant PCNA polypeptides.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Insect, Mouse, Non-human Primate, Rat, Yeast

Product Type

Antibody

Isotype

IgG2a

Applications

Immunohistochemistry (Paraffin), Western Blot

Clone

PC10

Conjugate

Biotin

Gene

Pcna

Gene Alias

ATLD2; cb16; Cyclin; DNA polymerase delta auxiliary protein; etID36690.10; fa28e03; fb36g03; HGCN8729; hypothetical protein LOC515499; MGC8367; Pcna; pcna protein; Pcna/cyclin; PCNAR; POL30; Proliferating cell nuclear antigen; wu:fa28e03; wu:fb36g03; YBR0811; YBR088C

Host Species

Mouse

Purification Method

purified

Regulatory Status

RUO

Gene ID (Entrez)

18538, 25737, 5111, 852385

Content And Storage

4° C

Form

Liquid

Description

  • PCNA (polymerase delta auxiliary protein) is essential for DNA replication and is involved in DNA excision and mismatch repair pathways
  • PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT)
  • PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumor tissue (i.e
  • relevant to prognosis)
  • PCNA is a marker for cells in early G1 phase and S phase of the cell cycle
  • PCNA is found in the nucleus and is a cofactor of DNA polymerase delta, and acts as a homotrimer and helps increase the processing of leading strand synthesis during DNA replication
  • In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway
  • Two transcript variants encoding the same protein have been found for PCNA
  • Pseudogenes of PCNA have been described on chromosome 4 and on the X chromosome.