Connexin 32 Monoclonal Antibody (Connexin32 (2A)), Biotin, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 13-975-980-Each-of-1 | In Stock | ₹ 11,659.00 |
13-975-980 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 11,659.00
GST (18%): ₹ 2,098.62
Total Price: ₹ 13,757.62
Antigen
Connexin 32
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P08033, P08034, P28230
Gene Symbols
GJB1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14618, 2705, 29584, 378797
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
Connexin32 (2A)
Conjugate
Biotin
Gene
GJB1
Gene Alias
CMTX; CMTX1; Cnx32; connexin 32; connexin-32; CX32; Cxn-32; GAP junction 28 kDa liver protein; gap junction beta-1 protein; gap junction membrane channel protein beta 1; gap junction protein beta 1; gap junction protein, beta 1; gap junction protein, beta 1, 32kDa; Gjb1
Host Species
Mouse
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Chicken, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- The Connexin32 MAb recognizes human, mouse, rat, and chicken Connexin 32
- Connexins are a family of integral membrane proteins that form gap junction channels, which function to facilitate direct cell-cell communication
- Gap junctions are comprised of two hemichannels, or connexons, which are made up of six connexin proteins
- Over 20 connexin proteins have been identified and each combine to form either homomeric or heteromeric channels with different functional properties
- Connexin 32 is expressed by myelin, neurons, oligodendrocytes, and hepatocytes, and plays a role in the development of ovarian follicles
- Connexin 32 expression also plays a role in disease progression in chronic multiple sclerosis and experimental autoimmune encephalomyelitis
- Mutations in the Connexin 32 gene, GJB1, result in a form of Charcot-Marie-Tooth disease which is characterized by peripheral nerve dysfunction
- Applications Reported: This Connexin32 antibody has been reported for use in western blotting, immunocytochemistry, immunohistochemical staining of frozen tissue sections, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections
- Applications Tested: This Connexin32 antibody has been tested by immunohistochemistry of frozen mouse tissue and can be used at less than or equal to 10 μg/mL
- It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
- Filtration: 0.2 μm post-manufacturing filtered
- This gene encodes a member of the gap junction protein family
- The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells
- According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta
- Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy
- Alternatively spliced transcript variants encoding the same protein have been found for this gene.