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14-038-937

CD38 Monoclonal Antibody (HIT2), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 14-038-937-Each-of-1 In Stock ₹ 1,22,642.00

14-038-937 - Each of 1

₹ 1,22,642.00

In Stock

Quantity

1

Base Price: ₹ 1,22,642.00

GST (18%): ₹ 22,075.56

Total Price: ₹ 1,44,717.56

Antigen

CD38

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P28907

Gene Symbols

CD38

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

952

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Immunohistochemistry (Paraffin)

Clone

HIT2

Conjugate

Unconjugated

Gene

CD38

Gene Alias

2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10

Host Species

Mouse

Quantity

2 mg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Description

  • Description: The HIT2 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein
  • CD38 is expressed by thymocytes, peripheral B cells including plasma cells, activated T cells, and monocytes
  • CD38 is a counter-receptor for CD31 and has both cyclase and hydrolase enzymatic activity
  • Applications Reported: The HIT2 antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining
  • Applications Tested: The HIT2 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells
  • This can be used at less than or equal to 1 μg per test
  • A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
  • Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
  • The HIT2 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retreival and can be used at less than or equal to 40 μg/mL
  • It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Aggregation: Less than 10%, as determined by HPLC
  • Filtration: 0.2 μm post-manufacturing filtered
  • CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells
  • CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor
  • Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e
  • identification of myelomas), and as a marker for activated B and T cells
  • CD38 participates in cell adhesion, signal transduction and calcium signaling
  • Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma
  • Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.