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14-039-937

CD39 Monoclonal Antibody (eBioA1 (A1)), eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 14-039-937-Each-of-1 In Stock ₹ 1,22,642.00

14-039-937 - Each of 1

₹ 1,22,642.00

In Stock

Quantity

1

Base Price: ₹ 1,22,642.00

GST (18%): ₹ 22,075.56

Total Price: ₹ 1,44,717.56

Antigen

CD39

Classification

Monoclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.

P49961

Gene Symbols

ENTPD1

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

953

Content And Storage

4° C

Form

Liquid

Applications

Flow Cytometry, Immunohistochemistry (Frozen)

Clone

eBioA1 (A1)

Conjugate

Unconjugated

Gene

ENTPD1

Gene Alias

2610206B08Rik; AA408691; ATPDase; Cd39; CD39 antigen; DKFZp686D194; DKFZp686I093; ecto-apyrase; Ecto-ATP diphosphohydrolase 1; ecto-ATPase 1; ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; ENTPD1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase-1; SPG64

Host Species

Mouse

Quantity

2 mg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Description

  • The eBioA1 MAb reacts with human CD39 also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) or NTPDase
  • CD39 is an integral membrane protein with two transmembrane domains and exists as a homotetramer
  • It is the most prominent ectoenzyme of the immune system
  • The function of CD39 is to effectively remove toxic extracellular ATP by converting it to ADP or AMP
  • CD39 is thought to work together with CD73 to hydrolyze ATP and has been well characterized on Langerhans cells
  • Expression of CD39 was originally identified on activated lymphocytes
  • Expression is also found on a subset of T cells, B cells and dendritic cells as well as weak staining on monocytes and granulocytes
  • Recently, CD39 and CD73 have been found on regulatory T cells (Treg)
  • Expression of CD39 on Treg may facilitate their entry into inflamed areas where high levels of ATP are present
  • Expression of CD39 on Foxp3+CD4+ cells ranges from 25-45%
  • CD39 cell surface antigen is a 70-100kD molecule expressed on peripheral blood B cells, monocytes, T cell clones, and also weakly expressed on granulocytes
  • CD39 has intrinsic ecto-ATPase activity
  • Expression of CD39 is induced on T cells and increased on B cells as a late activation antigen.