CD170 (Siglec F) Monoclonal Antibody (1RNM44N), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-170-295-Each-of-1 | In Stock | ₹ 3,08,830.00 |
14-170-295 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 3,08,830.00
GST (18%): ₹ 55,589.40
Total Price: ₹ 3,64,419.40
Antigen
CD170 (Siglec F)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q920G3
Gene Symbols
Siglecf
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
233186
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen)
Clone
1RNM44N
Conjugate
Unconjugated
Gene
Siglecf
Gene Alias
CD170; CD33 antigen-like 2; CD33L2; mSiglec-F; OB-binding protein 2; OBBP2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin F; sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin F; sialic acid-binding immunoglobulin-like lectin 5; sialic acid-binding lectin Siglec-F; Siglec; SIGLEC5; siglec-5; Siglecf; Siglec-F
Host Species
Rat
Quantity
10 mg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- This 1RNM44N MAb recognizes mouse CD170, also known as Siglec F
- Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types
- The cytoplasmic domain of Siglec F contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that initiates intracellular signaling upon ligand binding
- Siglec F is expressed mostly on eosinophils and alveolar macrophages and lower levels of this receptor have also been reported on immature myelomonocytic cells
- Mouse Siglec F is a functional ortholog of human Siglec 8, however, unlike human Siglec 8, mouse Siglec F is not expressed on mast cells
- This 1RNM44N antibody will recognize a formaldehyde-fixed epitope
- SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells
- This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid
- The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
- This molecule is expressed by monocytic/myeloid lineage cells
- SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus
- It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.