CD365 (Tim-1) Monoclonal Antibody (RMT1-4), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 14-586-182-Each | In Stock | ₹ 18,391.85 |
14-586-182 - Each
In Stock
Quantity
1
Base Price: ₹ 18,391.85
GST (18%): ₹ 3,310.533
Total Price: ₹ 21,702.383
Antigen
CD365 (Tim-1)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q5QNS5
Gene Symbols
Havcr1
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
171283
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry
Clone
RMT1-4
Conjugate
Unconjugated
Gene
Havcr1
Gene Alias
AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The RMT1-4 MAb reacts with mouse CD365 (also known as TIM1 and HAVCR1) and is a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family
- CD365 has been found on activated CD4+ T cells, mast cells, and a subset of B cells
- CD365 is involved in renal injury, tissue homeostasis, and T cell costimulation
- CD365 promotes the differentiation of Th2 cells and the production of IL-4
- CD365 can bind several ligands, including Hepatitis A virus, phosphatidylserine, TIM4, IgA, as well as itself
- CD365 and TIM4 can mediate uptake of apoptotic cells through recognition of phosphatidylserine
- CD365, as well as the other TIM family members, are associated with susceptibility to atopic and autoimmune diseases
- In humans, certain polymorphic variants of CD365 are strongly associated with protection against atopy, and this association occurs only in individuals who have had past infection with hepatitis A virus (HAV)
- CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail
- The endogenous ligand for CD365 is Tim-4
- In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus
- The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes
- Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity
- CD365 has also been implicated in the T cell co-stimulation
- CD365 is primarily expressed in epithelial cells
- It is also highly expressed in A549, 769-P and Caco-2 and cell lines
- CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.