CXCL12 beta (SDF-1 beta) Polyclonal Antibody, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-799-183-Each-of-1 | In Stock | ₹ 29,370.00 |
14-799-183 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 29,370.00
GST (18%): ₹ 5,286.60
Total Price: ₹ 34,656.60
Antigen
CXCL12 beta (SDF-1 beta)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cxcl12
Gene Alias
12-O-tetradecanoylphorbol 13-acetate repressed protein 1; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXC; CXC motif chemokine; C-X-C motif chemokine 12; C-X-C motif chemokine ligand 12; CXCL; CXCL12; Intercrine reduced in hepatomas; IRH; PBSF; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SCYB12; Sdf1; SDF-1; sdf-1 beta; SDF-1 gamma; SDF1A; SDF-1-alpha(3-67); SDF1B; SDF-1-beta(3-72); Stromal cell-derived factor 1; stromal cell-derived factor-1 gamma; thymic lymphoma cell-stimulating factor; TLSF; Tpar1
Host Species
Rabbit
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P40224
Gene Symbols
Cxcl12
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
20315, 24772
Content And Storage
4° C
Form
Liquid
Related Products
Description
- Description: The polyclonal antibody reacts with both mouse and rat CXCL12 beta (SDF-1 beta)
- It was generated using E
- coli-expressed N terminal amino acids 20-93 of mouse CXCL12 beta as an immunogen
- CXCL12 beta, also known as pre-B-cell growth-stimulating factor (PBSF) and stromal cell-derived factor-beta (SDF-1 beta), is a 74-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line
- Targeted deletion of CXCL12 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice
- CXCL12 has been shown to be chemotactic for lymphocytes
- In addition, CXCL12 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells
- CXCL12 binding to CXCR4 inhibits HIV-1 entry
- Applications Reported: This polyclonal can be used in immunoblotting (WB), immunoprecipitation, and immunohistochemistry
- Cross-reactivity to CXCL12 beta of other species has not been determined
- Applications Tested: To achieve best results, titrate antibody by dilution for each application as follows: Western Blot 1:1000 Immunoprecipitation 1:300-500 Immunohistochemistry 1:100-500
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family
- This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer
- Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections
- Multiple transcript variants encoding different isoforms have been found for this gene.