CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-901-982-Each-of-1 | In Stock | ₹ 26,344.00 |
14-901-982 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,344.00
GST (18%): ₹ 4,741.92
Total Price: ₹ 31,085.92
Antigen
CD266 (TWEAK Receptor)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q9NP84
Gene Symbols
TNFRSF12A
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51330
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone
ITEM-1
Conjugate
Unconjugated
Gene
TNFRSF12A
Gene Alias
AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; TNFRSF12A; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; Tweak-receptor; type I transmembrane protein Fn14
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein)
- Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region
- Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis
- TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1
- Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs
- Fn14 mRNA expression has been identified during liver regeneration
- TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines
- Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library
- TweakR is a small protein belonging to TNF receptor super family
- TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3
- TweakR mRNA is upregulated during tissue regeneration in the aorta and liver
- It may also play a role in vascular cell migration and angiogenesis.