Cytokeratin 18 Monoclonal Antibody (LDK18), eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each | 14-981-582-Each | In Stock | ₹ 31,652.85 |
14-981-582 - Each
In Stock
Quantity
1
Base Price: ₹ 31,652.85
GST (18%): ₹ 5,697.513
Total Price: ₹ 37,350.363
Antigen
Cytokeratin 18
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P05783
Gene Symbols
KRT18
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3875
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
LDK18
Conjugate
Unconjugated
Gene
KRT18
Gene Alias
cb83; Cell proliferation-inducing gene 46 protein; CK 18; CK18; CK-18; CYK18; cytokeratin 18; cytokeratin endo B; cytokeratin type -1; DAPK-1; Cytokeratin18; cytokeratin-18; dapk1; dorsal aorta proneprin kinesin-1; DreK18; Endo B; I79_023185; K 18; K18; keratin 18; keratin 18, type I; keratin 18a, tandem duplicate 1; keratin complex 1, acidic, gene 18; keratin D; Keratin, type I cytoskeletal 18; Keratin18; keratin-18; Kerd; KRT 18; Krt1-18; KRT18; krt18 {ECO:0000250; krt18a.1; LOC100008885; PIG46; sb:cb83; type I cytoskeletal 18; UniProtKB:P05783}; wu:fa13f02; wu:fb36b04
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The monoclonal antibody LDK18 recognizes human Cytokeratin 18
- Cytokeratin 18 is member of the large family of intermediate filaments found within epithelial cells
- The family of cytokeratins is made up of type I (acidic) and type II (basic) members which form heterodimers by pairing an acidic with a basic member to compose the keratin filament
- Cytokeratin 18 (type I) is most commonly found associated with cytokeratin 8 (type II)
- Because many tumors of epithelial origin retain expression of keratin proteins, cytokeratin 18 has been used as a tumor marker to identify both tumors and metastases
- In addition, cytokeratin 18 has been shown to be expressed in highly proliferative retinal pigment epithelium cells
- Applications Reported: This LDK18 antibody has been reported for use in western blotting, microscopy, immunohistochemical staining, and immunocytochemistry
- Applications Tested: This LDK18 antibody has been tested by immmunocytochemistry of MeOH-fixed human cells and can be used at less than or equal to 1 μg/mL
- It is recommended that the antibody be titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8
- Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18
- Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas
- Hepatocellular carcinomas express only cytokeratins 8 and 18
- Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis
- Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene
- Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies
- The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.