Cytokeratin 8 Monoclonal Antibody (LP3K), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 14-993-837-Each-of-1 | In Stock | ₹ 1,22,108.00 |
14-993-837 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,22,108.00
GST (18%): ₹ 21,979.44
Total Price: ₹ 1,44,087.44
Antigen
Cytokeratin 8
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P05787
Gene Symbols
KRT8
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3856
Content And Storage
4° C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Clone
LP3K
Conjugate
Unconjugated
Gene
KRT8
Gene Alias
AA960620; AL022697; AU019895; CARD2; cb186; CK8; CK-8; CYK8; CYKER; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin endo A; Cytokeratin-8; cytokeratin-A; DreK8; EndoA; etID33550.23; etID43142.23; etID43142.8; K2C8; K8; KERA; keratin 8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type 2, gene 8; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8-like protein; keratin-8; KO; Krt-2.8; Krt2-8; krt8; LOW QUALITY PROTEIN: keratin, type II cytoskeletal 8; sb:cb186; type II cytokeratin A (no.8); type-II keratin Kb8; wu:fa20h05; wu:fa95h10; wu:fb96c06; zfk8; zf-K8
Host Species
Mouse
Quantity
2 mg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- This LP3K MAb reacts with human cytokeratin 8 (K8), a 55-kDa member of the family of intermediate filament proteins
- Cytokeratin 8 is a type II (or basic) keratin that is expressed in epithelial and carcinoma cells
- Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues
- More specifically, studies have demonstrated the involvement of cytokeratin 8 in protection against apoptosis, stress, or injury, as well as regulation of the cell cycle
- This keratin is frequently co-expressed with cytokeratin 18, a type I (or acidic) keratin as a heterodimer
- Although detected primarily in the cytoplasm of normal healthy cells, cytokeratin 8 has been found to localize to the plasma membrane in some tumor cells
- Finally, cytokeratin 8 is phosphorylated on serine 73 in dividing cells
- Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12
- Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells
- Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells
- This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation
- Mutations in this gene cause cryptogenic cirrhosis.