15-988-342
HELIOS Monoclonal Antibody (22F6), PE-Cyanine5, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 15-988-342-Each-of-1 | In Stock | ₹ 38,003.00 |
15-988-342 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,003.00
GST (18%): ₹ 6,840.54
Total Price: ₹ 44,843.54
Antigen
HELIOS
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.
P81183, Q9UKS7
Gene Symbols
IKZF2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22779, 22807, 488510
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
22F6
Conjugate
PE-Cyanine5
Gene
IKZF2
Gene Alias
A730095J18Rik, ANF1A2, Helios, IKAROS family zinc finger 2, IKAROS family zinc finger 2 (Helios), ikaros family zinc finger protein 2, Ikzf2, Zfpn1a2, zinc finger DNA binding protein Helios, zinc finger protein Helios, zinc finger protein, subfamily 1A, 2 (Helios), ZNF1A2, Znfn1a2
Host Species
Armenian Hamster
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description: This 22F6 monoclonal antibody reacts with human, mouse and canine Helios
- Helios is a zinc-finger transcription factor first identified for its similarity to Ikaros
- It is expressed in hematopoietic stem cells in both the embryo and adult mice
- While the highest expression is found in regulatory T cells, Helios is not expressed in mature B cells, dendritic cells or myeloid cells
- Helios can form a homodimer as well as heterodimerize with other Ikaros family members to regulate transcription
- Eight isoforms of Helios exist, some of which possess a domit-negative function that has also been found to be upregulated in lymphoid maligcies, including T-acute lymphoblastic leukemia
- 22F6 has been reported to cross react with rat Helios
- Applications Reported: This 22F6 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This 22F6 antibody has been pre-diluted and tested by flow cytometric analysis of mouse lymph node cells using the Foxp3/Transcription Factor Staining Buffer Set (Product No
- 00-5523-00) and protocol
- Please refer to Staining Intracellular Antigens for Flow Cytometry, Protocol B: One step protocol for intracellular (nuclear) proteins located at www.thermofisher.com/flowprotocols
- This may be used at 5 μL (0.06 μg) per test
- This gene encodes a member of the Ikaros family of zinc-finger proteins
- Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development
- This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development
- Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.