CD8b Monoclonal Antibody (eBio341 (341)), Functional Grade, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 16-008-038-Each-of-1 | In Stock | ₹ 2,60,770.00 |
16-008-038 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 2,60,770.00
GST (18%): ₹ 46,938.60
Total Price: ₹ 3,07,708.60
Antigen
CD8b
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.2
Gene Accession No.
P05541
Gene Symbols
Cd8b
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
24931
Content And Storage
4° C
Form
Liquid
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin)
Clone
eBio341 (341)
Conjugate
Functional Grade
Gene
Cd8b
Gene Alias
CD8; CD8 antigen 37 kDa chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8a; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; CD8B1; CD8beta; CD8BP; LEU2; Leu-2; LY3; Ly-3; Ly-C; Lymphocyte antigen 3; Lyt3; Lyt-3; MAL; OX-8 membrane antigen; p32; P37; T lymphocyte surface glycoprotein beta chain; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3
Host Species
Mouse
Quantity
5 mg
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- The eBio341 MAb reacts with rat CD8beta
- CD8beta is a member of the immunoglobulin superfamily which heterodimerizes with CD8alpha to form the CD8 antigen expressed on CD4+CD8+, double-positive thymocytes, the majority of MHC class I-restricted peripheral T cells, and on some macrophages
- CD8beta expression is absent in athymic mice, which are populated by T-cells expressing CD8alpha homodimers
- This has led to the idea that CD8beta expression is dependent on the development of T cells in the thymus
- CD8 binds to MHC class I expressed on the surface of antigen-presenting cells during antigen presentation, and participates in T-cell receptor signal transduction through association with the kinase Lck
- The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system
- The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules
- The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain
- Both alpha and beta chains share significant homology to immunoglobulin variable light chains
- This gene encodes the CD8 beta chain isoforms
- Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described
- A pseudogene, also located on chromosome 2, has been identified.