200008398
CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), Brilliant Ultra Violet™ 615, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD274 (PD-L1, B7-H1)
Concentration
0.2 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide; pH 7.2
Gene Alias
A530045L16Rik; B7 homolog 1; B7-H; B7h1; B7-H1; Cd274; CD274 antigen; CD274 molecule; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; pdl-1; Programmed cell death 1 ligand 1; programmed death ligand 1; RGD1566211; sCD274; soluble CD274; soluble PD L1; sPD L1
Gene Symbols
Cd274
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Clone
MIH5
Applications
Flow Cytometry
Conjugate
Brilliant Ultraviolet 615
Host Species
Rat
Target Species
Mouse
Gene Accession No.
Q9EP73
Gene ID (Entrez)
60533
Isotype
IgG2a λ
Purification Method
Affinity chromatography
Gene
Cd274
Related Products
Description
- Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member
- To date, one specific receptor has been identified that can be ligated by PD-L1
- This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling
- Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production
- PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation
- Thus, PD-L1 might play an important role in tumor immune evasion.