200020196
TNNI1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TNNI1
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse, Porcine, Rat
Gene Accession No.
P13413, P19237, Q9WUZ5
Gene ID (Entrez)
21952, 29388, 396947, 7135
Immunogen
Recombinant Rat TNNI1 protein, Met1-Gln187 (Accession #P13413)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
SSTNI, TNN1
Gene Symbols
TNNI1
Isotype
IgG
Purification Method
Protein A
Gene
TNNI1
Related Products
Description
- Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles
- Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle
- TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation
- The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac
- The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue
- This gene encodes the Troponin-I-skeletal-slow-twitch protein
- This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults
- The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.