200020411
CD7 Monoclonal Antibody (D5), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD7
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
Cd7, CD7 antigen, CD7 antigen (p41), Cd7 molecule, GP40, LEU-9, p41 protein, T-cell antigen CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41
Gene Symbols
CD7
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
CD7
Clone
D5
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P09564
Gene ID (Entrez)
924
Immunogen
Recombinant Eukaryotic Human CD7 protein, Ala26-Pro180 (Accession #P09564)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily
- CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects
- CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia
- Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells
- Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation
- CD7 associates directly with phosphoinositol 3'-kinase
- CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation
- Expression of CD7 is an important marker used in leukemia diagnostics.