CD14 Monoclonal Antibody (61D3), Brilliant Violet™ 605, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD14
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Alias
CD 14, CD14, CD14 antigen, CD14 molecule, cd14 monocyte, lipopolysaccharide receptor, lipoprotein receptor, LPSR antibody, monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, monocyte differentiation antigen CD14, LOW QUALITY PROTEIN: monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein, myeloid membrane glycoprotein precursor, sCD14, soluble CD14
Gene Symbols
Cd14
Primary or Secondary
Primary
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Clone
61D3
Applications
Flow Cytometry
Conjugate
Brilliant Violet 605
Host Species
Mouse
Target Species
Human
Gene Accession No.
P08571
Gene ID (Entrez)
929
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Gene
Cd14
Related Products
Description
- CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils
- CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form
- CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein
- The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles
- Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes
- Alternative splicing results in multiple transcript variants encoding the same CD14 isoform
- Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.