CD71 (Transferrin Receptor) Monoclonal Antibody (R17217 (RI7 217.1.4)), PE-Cyanine7, eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 25-071-182-Each-of-1 | In Stock | ₹ 30,349.00 |
25-071-182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,349.00
GST (18%): ₹ 5,462.82
Total Price: ₹ 35,811.82
Antigen
CD71 (Transferrin Receptor)
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q62351
Gene Symbols
TFRC
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22042
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
R17217 (RI7 217.1.4)
Conjugate
PE-Cyanine7
Gene
TFRC
Gene Alias
2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Host Species
Rat
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG2a κ
Related Products
Description
- The R17217 MAb reacts with mouse CD71, a 170-180 kDa type II transmembrane protein
- CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth
- CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes
- Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71
- Expression level differences have been observed in different mouse strains
- Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes
- Endosomal acidification leads to iron release
- The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor
- Transferrin receptor is necessary for development of erythrocytes and the nervous system
- Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.