MAVS Monoclonal Antibody (ABM28H9), PE-Cyanine7, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 25-983-542-Each-of-1 | In Stock | ₹ 39,783.00 |
25-983-542 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,783.00
GST (18%): ₹ 7,160.94
Total Price: ₹ 46,943.94
Antigen
MAVS
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Accession No.
Q7Z434
Gene Symbols
MAVS
Immunogen
Recombinant fragment of human MAVS (aa 72-296)
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b κ
Applications
Flow Cytometry
Clone
ABM28H9
Conjugate
PE-Cyanine7
Gene
MAVS
Gene Alias
CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; D430028G21Rik; IFN-B promoter stimulator 1; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS1; IPS-1; KIAA1271; MAVS; mitochondrial antiviral signaling protein; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; VISA
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
57506
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
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Description
- This ABM28H9 MAb recognizes human MAVS, a mitochondrial membrane protein also known as VISA, CARDIF or IPS-1
- Two distinct signaling pathways activate the host innate immunity against viral infection
- One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response
- MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B
- MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6
- MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region
- Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system
- Multiple isoforms of MAVS are known to exist.