25-985-880
IRF4 Monoclonal Antibody (3E4), PE-Cyanine7, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 25-985-880-Each-of-1 | In Stock | ₹ 12,816.00 |
25-985-880 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 12,816.00
GST (18%): ₹ 2,306.88
Total Price: ₹ 15,122.88
Antigen
IRF4
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q15306, Q64287
Gene Symbols
IRF4
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16364, 3662
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
3E4
Conjugate
PE-Cyanine7
Gene
IRF4
Gene Alias
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP
Host Species
Rat
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Description: The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4)
- IRF4 is a 52 kDa transcription factor with roles in B cell, T cell and macrophage function
- In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation
- IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1
- In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function
- This transcription factor is upregulated upon T cell activation and is expressed in mature T cells
- Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression
- IRF4 has also been demonstrated to be involved in macrophage polarization and regulation
- Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers
- Applications Reported: This 3E4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis
- Applications Tested: This 3E4 antibody has been tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat 00-5523) and protocol
- IRF4 Monoclonal antibody specifically detects IRF4 in Human, Mouse samples
- It is validated for Flow Cytometry.