M-Cadherin Mouse, Unlabeled, Clone: 5, BD

Description

• Cadherins are a family of transmembrane glycoproteins involved in the Ca 2+ ;-dependent cell-cell adhesion that occurs in many tissues
• Members of this family include P-Cadherin, E-Cadherin (uvomorulin), N-Cadherin, R-Cadherin, Cadherin-5, L-CAM, and EP-Cadherin
• These proteins are similar in their domain structure (45-74% amino acid conservation), Ca 2+ ; and protease sensitivity, and molecular weight
• However, cadherins have distinct tissue expression patterns and immunological reactivities
• M (muscle)-Cadherin, another member of the Cadherin family, was discovered in myogenic mouse cells where it is present at low levels in myoblasts
• It is expressed in prenatal and adult skeletal muscle and plays a role in skeletal muscle cell differentiation, particularly the fusion of myoblasts into myotubes
• It is upregulated upon induction of myotube formation
• M-Cadherin also forms complexes with the catenins in skeletal muscle cells, which then interact with the cytoskeleton
• Therefore, it is thought that the M-Cadherin-cytoskeleton interaction may play a role in aligning myoblasts during fusion
• Immunofluorescence, Western Blotting