Desmoglein Mouse, Unlabeled, Clone: 62, BD

Description

• Desmoglein (Dsg1) is a transmembrane glycoprotein found in desmosome junctions
• Desmosomes and adherens junctions are plasma membrane specializations involved in cell-cell adhesion
• They serve as membrane anchorage domains for intermediate filaments and microfilaments, respectively
• Actin microfilaments anchor at adherens junctions, which occur in many sizes, shapes, and positions
• These junctions generally contain E- or N-Cadherin whose cytoplasmic region is associated with cytoplasmic proteins such as α- and β- catenin, vinculin, α-actinin, and radixin
• Intermediate filaments (IFs) are anchored at desmosomes which contain desmosome-specific cadherin family members, known as desmocollin (Dsc) and desmoglein
• These proteins associate with cytoplasmic proteins such as desmoplakin and plakoglobin (γ-Catenin)
• Plakoglobin is the only junctional protein found at both desmosomes and adherens junctions and, therefore, plays a crucial role in cell adhesion
• Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting