B2 Bradykinin Receptor Mouse, Unlabeled, Clone: 20, BD

Description

• Bradykinin is a nine amino acid vasoactive peptide that elicits numerous physiologic responses such as vasodilation, smooth muscle spasm, and pain
• Bradykinin is one of a family of such peptides called the kinins
• The kinins are generated from high molecular weight precursors called kininogens from proteolysis induced by pathophysiologic conditions such as inflammation or allergy
• The physiological actions of these kinins are mediated by their interaction with transmembrane receptors
• There are two distinct bradykinin receptor subtypes: B1 and B2
• Both are coupled to G-proteins
• The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas, the B1 receptors are only detected following tissue injury
• The B2 receptor is similar in structure to other seven helix G-protein coupled receptors
• Bradykinin has a relatively low affinity for B1 receptors, and interacts primarily with the B2 receptor
• This interaction stimulates several second messenger systems, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.