ALDH Mouse anti-Human, Unlabeled, Clone: 44, BD

Description

• Aldehyde dehydrogenase (ALDH) is a ubiquitous enzyme located in nearly all mammalian tissues
• It catalyzes the irreversible oxidation of a range of aliphatic and aromatic aldehydes to their corresponding carboxylic acids
• There are multiple isoforms of ALDH which are subdivided into three classes
• Class I includes the cytosolic isoforms
• Class II includes the mitochondrial isoforms
• Class III includes the microsomal, cytosolic tumor specific, and cytosolic dioxin-inducible forms
• At least twelve human ALDH isoforms have been identified
• Mutations of many of these proteins such as ALDH1, ALDH2, ALDH4, and ALDH10 have been implicated in multiple human metabolic disorders and clinical abnormalities
• At the amino acid level, human ALDH isoforms exhibit a wide range of diversity (15% to about 80%)
• However, multiple protein regions have been highly conserved and are important for functional activities
• A well-characterized member of the human ALDH family is ALDH1
• It plays a major role in the biosynthesis of retinoic acid from retinol (vitamin A)
• Retinoic acid, the biologically active form of retinol, is a regulator of cellular proliferation, differentiation, and survival
• Host Species: Mouse Clone: 44 Isotype: IgG1 Species Reactivity: Human Immunogen: Human ALDH1 aa
• 7-128 Formula Weight [Chemical]: 55kDa Immunofluorescence, Western Blotting