3968624
CD11b Rat anti-Mouse, PE-Cy7, Clone: M1/70, BD
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11b
Concentration
0.2mg/mL
Classification
Monoclonal
Host Species
Rat
Target Species
Human, Mouse
Isotype
IgG2b κ
Purification Method
Affinity Purified
Description
Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain
Clone
M1/70
Applications
Flow Cytometry
Conjugate
PE-Cyanine7
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The M1/70 antibody reacts with the 170kDa α[M] chain of Mac-1 (CD11b/CD18, α[M]β[2] integrin), also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54)
- Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 cells
- Mac-1 expression is rapidly up-regulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface
- M1/70 antibody reportedly blocks cell adherence and C3bi binding, but it does not block cell-mediated lysis
- Cross-reaction of mAb M1/70 with CD11b on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported
- This antibody is routinely tested by flow cytometric analysis
- Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
- Host Species: Rat Clone: M1/70 Isotype: IgG2b κ Species Reactivity: Mouse Immunogen: Mouse splenic Cells Flow Cytometry