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3969745

CD45 Rat anti-Mouse, Biotin, Clone: 30-F11, BD

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

CD45

Concentration

0.5mg/mL

Classification

Monoclonal

Host Species

Rat

Research Discipline

Immunology

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Isotype

IgG2b κ

Purification Method

Affinity Purified

Description

Ptprc; CD45R; LCA; Leukocyte common antigen; T200; B220; Ly-5; Lyt-4

Clone

30-F11

Applications

Flow Cytometry

Conjugate

Biotin

Regulatory Status

RUO

Target Species

Mouse

Immunogen

Mouse Thymus or Spleen

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Description

  • The 30-F11 clone has been reported to react with all isoforms and both alloantigens of CD45, which is found on hematopoietic stem cells and all cells of hematopoietic origin, except erythrocytes
  • CD45 is a transmembrane glycoprotein which is expressed at high levels on the cell-surface, and its presence distinguishes leukocytes from non-hematopoietic cells
  • CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family, where the intracellular carboxy-terminal region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated as A, B, and C, respectively)
  • CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction and the CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific
  • This antibody is routinely tested by flow cytometric analysis
  • Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
  • Host Species: Rat Clone: 30-F11 Isotype: IgG2b κ Species Reactivity: Mouse Immunogen: Mouse Thymus or Spleen Flow Cytometry