3971736
PI3-Kinase Mouse, Unlabeled, Clone: 4, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
PI3-Kinase
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG2a
Purification Method
Affinity Purified
Clone
4
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Chicken, Human, Mouse, Rat
Immunogen
Human PI3-Kinase α subunit aa. 562 to 724
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- PI3-kinase phosphorylates the D-3 position of the inositol ring of phosphatidylinositol (PtdIns), PtdIns(4)P and PtdIns(4,5)P2 to produce the respective PI3-phosphorylated derivatives
- PI3-kinase exists as a heterodimer of 85 kDa (p85) and 110 kDa (p110) subunits
- The p85 subunit contains two SH2 domains and an SH3 domain
- It associates with and serves as a substrate for activated growth factor receptor tyrosine kinases
- p85 may serve as regulator of the catalytic subunit, p110, by acting as the link between PI3-kinase and the ligand-activated receptor
- Two distinct forms of the p85 subunit have been described: 1) p85 α; , which binds tightly to the catalytic subunit, and 2) p85ß, a protein whose function is presently unknown
- Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.