40-471-6942
IL-17F Monoclonal Antibody (SHLR17), Brilliant Violet™ 421, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-471-6942-Each-of-1 | In Stock | ₹ 31,951.00 |
40-471-6942 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,951.00
GST (18%): ₹ 5,751.18
Total Price: ₹ 37,702.18
Antigen
IL-17F
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.
Q96PD4
Gene Symbols
IL17F
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
112744
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
SHLR17
Conjugate
Brilliant Violet 421
Gene
IL17F
Gene Alias
C87042, CANDF6, cytokine ML-1, IL17F, IL-17F, IL-24, ILN, Interleukin, interleukin 17F, Interleukin17F, interleukin-17F, interleukin-24, ML1, ML-1, mutant IL-17F
Host Species
Rat
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
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Description
- IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils
- IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils
- IL-17F may be secreted as a homodimer, or a heterodimer with IL17A
- It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production
- IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis
- TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines
- IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells
- IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.