CD366 (TIM3) Monoclonal Antibody (F38-2E2), Brilliant Violet™ 605, eBioscience™, Invitrogen™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 40-631-0942-Each-of-1 | In Stock | ₹ 31,951.00 |
40-631-0942 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,951.00
GST (18%): ₹ 5,751.18
Total Price: ₹ 37,702.18
Antigen
CD366 (TIM3)
Classification
Monoclonal
Concentration
5 μL/Test
Formulation
PBS with BSA and 0.09% sodium azide, pH 7.2
Gene Accession No.
Q8TDQ0
Gene Symbols
Havcr2
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
84868
Content And Storage
4°, C, store in dark, DO NOT FREEZE!
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
F38-2E2
Conjugate
Brilliant Violet 605
Gene
Havcr2
Gene Alias
CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3
Host Species
Mouse
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells
- TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region
- TIM3 is involved in macrophage activation and induction of autoimmune diseases
- Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance
- Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.